人口健康与生物医药领域关键共性技术、人口健康与生物医药领域关键共性技术、

颠覆性技术和重大产品研发、颠覆性技术和重大产品研发、

应用转化与技术服务应用转化与技术服务

蛋白分析研究组
研究方向

致力于开发基于成像的单细胞(空间)蛋白质组学技术,通过可视化解析蛋白质在单细胞分辨水平上的亚细胞定位、表达、修饰、空间分布与互作网络,为细胞分化、组织发育、疾病发生发展机制等生物医学研究提供全新的视角和研究手段。

我们的研究方向主要包括:

1. 微芯片电泳分离分析新方法、新技术的开发及应用研究;

2. 生物正交反应与调控技术的开发及应用研究;

3. 单细胞(空间)多组学联合分析及基于成像的功能蛋白质组学分析。


科研项目
科研成果

· 代表性论文:

· (1) Ting Zhang; Shanhe Li; Antony R Warden; Behafarid Ghalandari; Hongxia Li; Xiao Zhi; Haiyang Xie*; Xianting Ding*; A Photoclick Hydrogel for Enhanced Single-cell Immunoblotting, Advanced Functional Materials, 2020, 30(17): 1910739

· (2) Shanhe Li; Ze Wen; Behafarid Ghalandari; Tianhao Zhou; Antony R. Warden; Ting Zhang; Peng Dai; Youyi Yu; Wenke Guo; Mofang Liu;  Haiyang Xie*; Xianting Ding*; Single-Cell Immunoblotting based on a Photoclick Hydrogel Enables High-Throughput Screening and Accurate Profiling of Exogenous Gene Expression, Advanced Materials, 2021, 33(22): 210110

· (3) Haiyang Xie; Xianting Ding; The intriguing landscape of single-cell protein analysis, Advanced Science, 2022, 210593

· (4) Li Xu#; Haiyang Xie#; Boqian Wang#; Zijian Zhu; Hui Jiang; Xiaoqian Duan; Shuxin Deng; Jiasu Xu; Lai Jiang; Xianting Ding ; Multiplex Protein Profiling by Low-Signal-Loss Single-Cell Western Blotting with Fluorescent-Quenching Aptamers, Analytical Chemistry, 2023, 95(30): 11399-11409

· (5) Haiyang Xie#; Wenke Guo#; Hui Jiang#; Ting Zhang; Lei Zhao; Jinjuan Hu; Shuxin Gao; Sunfengda Song; Jiasu Xu; Li Xu; Xinyi Sun; Yi Ding; Lai Jiang; Xianting Ding*; Photosensitive Hydrogel with Temperature-Controlled Reversible Nano-Apertures for Single-Cell Protein Analysis, Advanced Science, 2024, 11, 2308569


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